Modafinil is a wake-promoting medication that improves daytime sleepiness in people with narcolepsy. It also reduces cataplexy. It is well tolerated and carries a low risk of dependency. Most people with narcolepsy benefit from its use, especially when it is combined with other sleep strategies and medications to treat other disorders (like oxybates). Nurses can optimize patient outcomes by carefully monitoring medications.

Dosage

Buy Modafinil Online is a drug that increases wakefulness and enhances cognitive function, notably alertness, attention, and memory. Modafinil also has been shown to improve decision-making and planning. It has been used successfully in patients with shift work sleep disorder (SWSD), allowing them to work more effectively during non-traditional hours, as well as to treat obstructive sleep apnea/hypopnea syndrome.

Modalin can be abused or misused, and may cause psychological or physical dependence. Use only as directed by your doctor. Modafinil does not replace getting enough sleep, and should not be used to treat non-narcolepsy related excessive daytime sleepiness. Continue to follow your doctor’s advice about good sleep habits, and use a breathing device as prescribed if you have obstructive sleep apnea/hypopnea.

In narcolepsy studies, a 400-mg once-daily dose significantly improved wakefulness during the day compared to placebo at baseline. The same was true in a study of patients with OSA. Modafinil was well tolerated in both narcolepsy and OSA patients.

Modafinil is metabolized by the liver, and approximately 80% of the dose is eliminated in urine as metabolites. It has a low rate of absorption from the digestive tract, and is therefore taken orally. Severe renal and hepatic impairment can reduce the clearance of modafinil. Patients with severe hepatic impairment should be carefully monitored to avoid exceeding the maximum recommended daily dose of 200 mg.

Side Effects

Modafinil is a wakefulness agent that selectively targets neuronal pathways in the brain sleep/wake centers. It is absorbed well and is metabolized via amide hydrolysis and CYP-mediated oxidation. Less than 10% of the dose is excreted as unchanged drug.

Modalert Tablet is well-tolerated and has a lower abuse potential than other central nervous system stimulants like amphetamines. In placebo-controlled clinical trials, it reduces excessive daytime sleepiness in narcolepsy patients. It also improves alertness and cognitive functioning in obstructive sleep apnea, idiopathic hypersomnia, and shift work disorder patients.

Modafinil increases levels of histamine in the brain, which contributes to its wake-promoting effects. It also increases levels of norepinephrine, another neurotransmitter that enhances arousal and attention. It may also modulate gamma-aminobutyric acid (GABA) transmission, although this is less clear.

The most common side effects of Modafinil include headache, nausea, and insomnia. These are typically mild and go away as the body adjusts to the medication. If they persist, speak to your physician as adjustments in dosage or timing can help reduce them.

In some cases, modafinil can cause mental health symptoms such as hallucinations, depression, or psychosis. Stop taking modafinil and call your healthcare professional right away if you have these symptoms. Modafinil can also affect your heart rate, so it's important to tell your doctor if you have heart disease or high blood pressure.

Interactions

Modafinil interacts with certain other medications and may cause serious side effects if taken with certain medicines. Tell your doctor or healthcare professional about all the medicines, herbs, vitamins, and supplements you are taking or plan to take. Also tell them if you smoke or drink alcohol. They can help you avoid interactions and get the most benefit from this medication.

Modafinil increases wakefulness by blocking the reuptake of dopamine and norepinephrine in brain areas that are involved in sleep-wake cycles and alertness. It also stimulates adenosine activity, another natural substance that increases wakefulness. Modafinil also affects the transmission of glutamate in the brain, although the exact mechanism is not known. Glutamate is an excitatory neurotransmitter that plays a role in memory and learning.

Several studies have found that modafinil improves fatigue and wakefulness in people with major depression who are receiving selective serotonin reuptake inhibitor (SSRI) antidepressants. It is important that you continue to receive the other treatment for your depression as well as this medicine.

Modafinil can interact with other medicines that treat narcolepsy, obstructive sleep apnea/hypopnea syndrome, and shift work sleep disorder. If you are taking these medicines, your doctor will probably prescribe a lower dose of modafinil. He or she may also recommend that you take modafinil at least 2 hours before these medicines.

Precautions

Modafinil is FDA-approved for treating narcolepsy and obstructive sleep apnea/hypopnea syndrome (OSAHS). It has also been shown to improve real and simulated driving performance in patients with hypersomnia.

It is important to follow the dosage instructions provided by your doctor. Never exceed the recommended dose without their supervision. This medicine may cause dizziness, so it is not safe to drive or operate machinery until you know how it affects you. You should also avoid alcoholic beverages while taking this medication. This medicine can affect the effectiveness of birth control pills, so if you use them, talk to your doctor about using an alternative method of contraception.

Long-term use of this drug can lead to tolerance, requiring higher doses to achieve the same effect. This can increase your risk of misuse and dependence. Abrupt discontinuation of this medication can trigger withdrawal symptoms in some people.

Tell your doctor if you have any mental health symptoms, especially depression or psychosis. If you become agitated or restless while taking this medication, contact your doctor right away. This drug can increase your blood pressure. It is important to have your blood pressure checked often while taking this medication. This medication may also interact with a number of other drugs. Give your doctor a complete list of all prescription, nonprescription, and herbal medicines you are taking, as well as any other drugs you may be allergic to.